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Comparative Study
. 1990 Sep-Nov;237(5-6):239-46.
doi: 10.1016/0921-8734(90)90005-c.

Comparison of age-associated changes of c-myc gene methylation in liver between man and mouse

T Ono  1 , S Yamamoto, A Kurishita, K Yamamoto, Y Yamamoto, Y Ujeno, K Sagisaka, Y Fukui, M Miyamoto, R Tawa, et al.
Affiliations
Comparative Study

Comparison of age-associated changes of c-myc gene methylation in liver between man and mouse

T Ono et al. Mutat Res. 1990 Sep-Nov.

Abstract

Age-associated changes in DNA methylation of the c-myc gene in liver were compared between humans and mice which have large differences in aging rate. Although the overall methylation profiles of the gene and their age-related changes were found to be similar, the rate of change was much slower in humans than in mice. It suggests that the age-associated alteration of c-myc gene methylation is closely related to biological aging rather than to chronological aging.

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