Case Reports
doi: 10.1159/000186190.
Acyclovir-induced acute tubulo-interstitial nephritis
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- PMID: 2080005
- DOI: 10.1159/000186190
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Case Reports
Acyclovir-induced acute tubulo-interstitial nephritis
Nephron.
1990.
Abstract
Two patients with presumed herpes simplex encephalitis developed severe non-oliguric acute renal failure shortly after acyclovir infusions. Renal function returned to normal in less than 3 weeks after discontinuation of acyclovir. Renal biopsies done during the acute phase demonstrated interstitial oedema, eosinophils and cellular aggregates in both and granulomata in the second case suggesting acyclovir-induced hypersensitivity interstitial nephritis.
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