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Controlled Clinical Trial
. 2010 Sep;96(17):1379-84.
doi: 10.1136/hrt.2009.192419.

Pulmonary venous isolation by antral ablation with a large cryoballoon for treatment of paroxysmal and persistent atrial fibrillation: medium-term outcomes and non-randomised comparison with pulmonary venous isolation by radiofrequency ablation

Pipin Kojodjojo  1 , Mark D O'Neill, Phang Boon Lim, Louisa Malcolm-Lawes, Zachary I Whinnett, Tushar V Salukhe, Nicholas W Linton, David Lefroy, Anthony Mason, Ian Wright, Nicholas S Peters, Prapa Kanagaratnam, D Wyn Davies
Affiliations
Controlled Clinical Trial

Pulmonary venous isolation by antral ablation with a large cryoballoon for treatment of paroxysmal and persistent atrial fibrillation: medium-term outcomes and non-randomised comparison with pulmonary venous isolation by radiofrequency ablation

Pipin Kojodjojo et al. Heart. 2010 Sep.

Abstract

Background: To prevent atrial fibrillation (AF) recurrence after catheter ablation, pulmonary venous isolation (PVI) at an antral level is more effective than segmental ostial ablation. Cryoablation around the pulmonary venous (PV) ostia for AF therapy is potentially safer compared to radiofrequency ablation (RFA). The aim of this study was to investigate the efficacy of a strategy using a large cryoablation balloon to perform antral cryoablation with 'touch-up' ostial cryoablation for PVI in patients with paroxysmal and persistent AF.

Methods: Paroxysmal and persistent AF patients undergoing their first left atrial ablation were recruited. After cryoballoon therapy, each PV was assessed for isolation and if necessary, treated with focal ostial cryoablation until PVI was achieved. Follow-up with Holter monitoring was performed. Clinical outcomes of the cryoablation protocol were compared, with consecutive patients undergoing PVI by RFA.

Results: 124 consecutive patients underwent cryoablation. 77% of paroxysmal and 48% of persistent AF subjects were free from AF at 12 months after a single procedure. Over the same time period, 53 consecutive paroxysmal AF subjects underwent PVI with RFA and at 12 months, 72% were free from AF at 12 months (p=NS). There were too few persistent AF subjects (n=8) undergoing solely PVI by RFA as a comparison group. Procedural and fluoroscopic times during cryoablation were significantly shorter than RFA.

Conclusions: PV isolation can be achieved in less than 2 h by a simple cryoablation protocol with excellent results after a single intervention, particularly for paroxysmal AF.

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Conflict of interest statement

Competing interests: None.

Figures

Figure 1
Figure 1
Positions of inflated 28 mm cryoballoon at the four pulmonary venous antra in the same paroxysmal atrial fibrillation (AF) patient. Note the hold-up of contrast in the pulmonary veins due to balloon occlusion of the antra. A quadripolar catheter is positioned in the superior vena cava to capture the right phrenic nerve. All four pulmonary veins (PV) were isolated after two cryoballoon applications to each PV.
Figure 2
Figure 2
Survival curves of subjects undergoing cryoablation. PAF, paroxysmal atrial fibrillation; Per AF, persistent atrial fibrillation. Comparison between PAF and Per AF curves, p=0.002.
Figure 3
Figure 3
Survival curves of paroxysmal atrial fibrillation subjects undergoing cryoablation and conventional radiofrequency ablation. Comparison between conventional radiofrequency ablation and cryoablation survival curves, p=NS.
See this image and copyright information in PMC

References

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