Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Sep;16(9):995-7.
doi: 10.1038/nm.2203. Epub 2010 Aug 29.

Adaptation of HIV-1 envelope gp120 to humoral immunity at a population level

Evelien M Bunnik  1 , Zelda Euler, Matthijs R A Welkers, Brigitte D M Boeser-Nunnink, Marlous L Grijsen, Jan M Prins, Hanneke Schuitemaker
Affiliations

Adaptation of HIV-1 envelope gp120 to humoral immunity at a population level

Evelien M Bunnik et al. Nat Med. 2010 Sep.

Abstract

By comparing HIV-1 variants from people who became infected at the beginning of the epidemic and from people who have recently contracted the virus, we observed an enhanced resistance of the virus to antibody neutralization over time, accompanied by an increase in the length of the variable loops and in the number of potential N-linked glycosylation sites on the HIV-1 envelope gp120 subunit. The enhanced neutralization resistance of HIV-1 in contemporary seroconverters coincided with the poorer elicitation of neutralizing antibody responses, which may have implications for vaccine design.

PubMed Disclaimer

References

    1. Nature. 2009 Apr 2;458(7238):641-5 - PubMed
    1. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4144-9 - PubMed
    1. J Infect Dis. 2010 Apr 1;201(7):1045-53 - PubMed
    1. J Virol. 2008 Aug;82(16):7932-41 - PubMed
    1. J Infect Dis. 1997 Feb;175(2):283-91 - PubMed

Publication types

MeSH terms