doi: 10.1002/chem.201001327.
Epub 2010 Aug 27.
Corozalic acid: a key okadaic acid biosynthetic precursor with phosphatase inhibition activity
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- PMID: 20803584
- DOI: 10.1002/chem.201001327
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Corozalic acid: a key okadaic acid biosynthetic precursor with phosphatase inhibition activity
Chemistry.
.
Abstract
Toxin precursors: Corozalic acid, a new Ser/Thr protein phosphatase 1 and 2A inhibitor that turned out to be a key metabolic intermediate, was isolated from cultures of the marine dinoflagellate Prorocentrum belizeanum. Detailed spectroscopic analysis and extensive computational calculations revealed its structure and conformational behavior. In addition, a comprehensive picture of the interactions of corozalic acid with PP1 and PP2A is proposed (see figure) on the basis of ab initio, docking and molecular dynamics calculations.
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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