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Randomized Controlled Trial
. 2010 Jun;20(5):691-4.

The effect of oral clonidine premedication on nausea and vomiting after ear surgery

Arman Taheri  1 , Mohammad Ali Javadimanesh, Haleh Ashraf
Affiliations
  • PMID: 20803858
Randomized Controlled Trial

The effect of oral clonidine premedication on nausea and vomiting after ear surgery

Arman Taheri et al. Middle East J Anaesthesiol. 2010 Jun.

Abstract

Objective: Postoperative nausea and vomiting (PONV) is a most distressing adverse event for surgical patients with a considerable economic impact .The aim of the present study was to evaluate the effect of clonidine given orally for PONV in patients undergoing anesthesia for outpatient ear surgery.

Methods: Sixty patients 30.2 +/- 9.9 years, scheduled for ear surgery, were randomly assigned to one of two groups (clonidine or placebo) in a double-blinded manner. Anesthesia was standardized laryngeal mask airway, fentanyl, propofol, halothane, nitrous oxide.

Results: A complete response, defined as no PONV and no need for rescue antiemetic medication, during the first 24 h after anesthesia was 33% with placebo and 67% with clonidine, respectively (P. 0.01). No clinically adverse event was observed in any of the groups.

Conclusion: Oral premedication with clonidine reduced the rate of PONV in patients undergoing outpatient ear surgery.

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