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. 2010 Aug 26;2(8):57.
doi: 10.1186/gm178.

Predictive, preventive, personalized and participatory medicine: back to the future

Affiliations

Predictive, preventive, personalized and participatory medicine: back to the future

Charles Auffray et al. Genome Med. .

Abstract

The pioneering work of Jean Dausset on the HLA system established several principles that were later reflected in the Human Genome Project and contributed to the foundations of predictive, preventive, personalized and participatory (P4) medicine. To effectively develop systems medicine, we should take advantage of the lessons of the HLA saga, emphasizing the importance of exploring a fascinating but mysterious biology, now using systems principles, pioneering new technology developments and creating shared biological and information resources.

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References

    1. Charron DJ. Obituary: Jean Dausset (1916-2009). Nature. 2009;460:338. doi: 10.1038/460338a. - DOI - PubMed
    1. Charron DJ. Immunogenetics today: HLA, MHC and much more. Curr Opin Immunol. 2005;17:493–497. doi: 10.1016/j.coi.2005.07.007. - DOI - PubMed
    1. Auffray C, Chen Z, Hood L. Systems medicine: the future of medical genomics and healthcare. Genome Med. 2009;1:2. doi: 10.1186/gm2. - DOI - PMC - PubMed
    1. Clermont G, Auffray C, Moreau Y, Rocke DM, Dalevi D, Dubhashi D, Marshall DR, Raasch P, Dehne F, Provero P, Tegner J, Aronow BJ, Langston MA, Benson M. Bridging the gap between systems biology and medicine. Genome Med. 2009;1:88. doi: 10.1186/gm88. - DOI - PMC - PubMed
    1. Hood L, Heath JR, Phelps ME, Lin B. Systems biology and new technologies enable predictive and preventative medicine. Science. 2004;306:640–643. doi: 10.1126/science.1104635. - DOI - PubMed