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Comment
. 2010 Sep 3;7(3):271-2.
doi: 10.1016/j.stem.2010.08.008.

Cancer cell of origin: spotlight on luminal progenitors

Christine L Chaffer  1 , Robert A Weinberg
Affiliations
Comment

Cancer cell of origin: spotlight on luminal progenitors

Christine L Chaffer et al. Cell Stem Cell. .

Abstract

Does basal type breast cancer arise from oncogenic transformation of a basal cell type? In this issue Molyneux and colleagues investigate the provenance of the basal-type BRCA1 breast carcinoma and come up with unanticipated results.

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Figures

Figure 1
Figure 1. Schematic diagram of a mammary stem cell hierarchy
In this diagram, a luminal ER- progenitor cell (CD24+/HighSca1-ER-) acquires a BRCA1 mutation and subsequently transitions into an aberrant basal progenitor cell (or directly differentiates into aberrant basal –like cells) and thus gives rise to BRCA1- mutant basal-like breast carcinoma. It is also possible that luminal ER- progenitor cells can transdifferentiate into basal progenitor cells as part of a normal physiological process, either directly (depicted by arrow with a question mark) or first via dedifferentiation to a common progenitor/stem cell
See this image and copyright information in PMC

Comment on

References

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