Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link

doi:10.1093/qjmed/hcq148

Review

. 2010 Nov;103(11):831-6.

doi: 10.1093/qjmed/hcq148. Epub 2010 Aug 30.

Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link

H Conroy¹, L Mawhinney, S C Donnelly

Affiliations

PMID: 20805118
PMCID: PMC2955282
DOI: 10.1093/qjmed/hcq148

Review

Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link

H Conroy et al. QJM. 2010 Nov.

. 2010 Nov;103(11):831-6.

doi: 10.1093/qjmed/hcq148. Epub 2010 Aug 30.

Authors

H Conroy¹, L Mawhinney, S C Donnelly

Affiliation

¹ Conway Institute for Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland.

PMID: 20805118
PMCID: PMC2955282
DOI: 10.1093/qjmed/hcq148

Abstract

Macrophage migration inhibitory factor (MIF) was the original cytokine, described almost 50 years ago and has since been revealed to be an important player in pro-inflammatory diseases. Recent work using MIF mouse models has revealed new roles for MIF. In this review, we present an increasing body of evidence implicating the key pro-inflammatory cytokine MIF in specific biological activities related directly to cancer growth or contributing towards a microenvironment favouring cancer progression.

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References

1. Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B. An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA. 1975;72:3666–70. - PMC - PubMed
1. Bloom BR, Bennett B. Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science. 1966;153:80–2. - PubMed
1. David JR. Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. Proc Natl Acad Sci USA. 1966;56:72–7. - PMC - PubMed
1. Rossi AG, Haslett C, Hirani N, Greening AP, Rahman I, Metz CN, et al. Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma. J Clin Invest. 1998;101:2869–74. - PMC - PubMed
1. Imamura K, Nishihira J, Suzuki M, Yasuda K, Sasaki S, Kusunoki Y, et al. Identification and immunohistochemical localization of macrophage migration inhibitory factor in human kidney. Biochem Mol Biol Int. 1996;40:1233–42. - PubMed

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[1] Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B. An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA. 1975;72:3666–70. - PMC - PubMed

[2] Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B. An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA. 1975;72:3666–70. - PMC - PubMed

[3] Bloom BR, Bennett B. Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science. 1966;153:80–2. - PubMed

[4] Bloom BR, Bennett B. Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science. 1966;153:80–2. - PubMed

[5] David JR. Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. Proc Natl Acad Sci USA. 1966;56:72–7. - PMC - PubMed

[6] David JR. Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. Proc Natl Acad Sci USA. 1966;56:72–7. - PMC - PubMed

[7] Rossi AG, Haslett C, Hirani N, Greening AP, Rahman I, Metz CN, et al. Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma. J Clin Invest. 1998;101:2869–74. - PMC - PubMed

[8] Rossi AG, Haslett C, Hirani N, Greening AP, Rahman I, Metz CN, et al. Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma. J Clin Invest. 1998;101:2869–74. - PMC - PubMed

[9] Imamura K, Nishihira J, Suzuki M, Yasuda K, Sasaki S, Kusunoki Y, et al. Identification and immunohistochemical localization of macrophage migration inhibitory factor in human kidney. Biochem Mol Biol Int. 1996;40:1233–42. - PubMed

[10] Imamura K, Nishihira J, Suzuki M, Yasuda K, Sasaki S, Kusunoki Y, et al. Identification and immunohistochemical localization of macrophage migration inhibitory factor in human kidney. Biochem Mol Biol Int. 1996;40:1233–42. - PubMed

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Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link

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Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link

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