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Case Reports
. 2011 Jan 11;183(1):E61-4.
doi: 10.1503/cmaj.091496. Epub 2010 Aug 30.

Intracerebral hemorrhage in a young man

Shelagh B Coutts  1 , Uta Matysiak-Scholze, Jürgen Kohlhase, A Micheil Innes
Affiliations
Case Reports

Intracerebral hemorrhage in a young man

Shelagh B Coutts et al. CMAJ. .
No abstract available

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Figures

Figure 1:
Figure 1:
(A) Computed tomographic scan and (B) magnetic resonance images (with fluid attenuated inversion recovery pulse sequences) of the brain of a 27-year-old man showing representative slices of the hemorrhage in the left basal ganglia (solid white arrows). The magnetic resonance images show diffuse white matter hyperintensity within the deep white matter of both cerebral hemispheres (dashed arrow). (C) Gradient echo image showing dark areas, which represent the acute deep hemorrhage and the presence of previous hemorrhages that had been clinically asymptomatic (black arrow). (D) Retinal photograph of the left eye showing tortuous retinal vessels.
Figure 2:
Figure 2:
(A) Lateral view, late arterial phase of right internal carotid angiogram. (B) The magnified view shows small, irregular, tortuous distal arterial branches in bilateral carotid and basilar arterial territories (arrow).
Figure 3:
Figure 3:
DNA sequencing of a COL4A1 complementary DNA product obtained by reverse-transcriptase polymerase chain reaction shows lack of exon 25 sequence between exon 24 and exon 26 resulting from the mutation c.1537–2delA in intron 24 of the COL4A1 gene.
See this image and copyright information in PMC

References

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    1. van der Knaap MS, Smit LM, Barkhof F, et al. Neonatal porencephaly and adult stroke related to mutations in collagen IV A1. Ann Neurol 2006;59:504–11 - PubMed
    1. Vahedi K, Kubis N, Boukobza M, et al. COL4A1 mutation in a patient with sporadic, recurrent intracerbral hemorrhage. Stroke 2007;38:1461–4 - PubMed
    1. Plaisier E, Gribouval O, Alamowitch S, et al. COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms and muscle cramps. N Engl J Med 2007; 357:2687–95 - PubMed
    1. GeneTests [homepage]. Bethesda (MD): National Center for Biotechnology Information; 2010. Available: www.ncbi.nlm.nih.gov/sites/GeneTests/?db=GeneTests (accessed 2009 Nov. 13).

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