Oxygen and oxidative stress in bronchopulmonary dysplasia

Abstract

Aims: to summarize present knowledge regarding the relation between oxidative stress and development of bronchopulmonary dysplasia (BPD).

Methods: relevant literature searched at Pubmed and other sources.

Results: Oxidative stress is generated in a number of conditions and by a number of causes such as inflammation and hyperoxia. Ontogenic aspects are discussed. Oxidative stress as physiological regulators, its relation to transcription factors and inflammation is summarized. The role of oxygen and antioxidant therapy and newborn resuscitation for development and prevention of BPD as well as new therapeutic modes especially the use of growth factors, gene therapy and stem cells, are briefly discussed.

Conclusion: oxidative stress and BPD are associated. A better understanding of this association is necessary in order to reduce the severity and the incidence of the condition.