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Review
. 2010 Sep;103(9):357-62.
doi: 10.1258/jrsm.2010.100033.

Beyond statin therapy: a review of the management of residual risk in diabetes mellitus

Eoin P Judge  1 , D Phelan, Donal O'Shea
Affiliations
Review

Beyond statin therapy: a review of the management of residual risk in diabetes mellitus

Eoin P Judge et al. J R Soc Med. 2010 Sep.

Abstract

Total cholesterol and low-density lipoprotein (LDL) cholesterol exhibit an independent, strong, continuous correlation with cardiovascular events. The effectiveness of hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) in the treatment and prevention of atherosclerosis is well-established. However, despite the lowering of LDL targets and the increased use of statins, patients with type 2 diabetes mellitus (DM) continue to experience a higher proportion of adverse coronary artery disease events. This is as a result of an atherogenic dyslipidaemia, characterized by low levels of high-density lipoprotein and elevated plasma triglyceride concentrations, often with high levels of cholesterol-rich remnant particles. This article will review dyslipidaemia and its role in DM, and will discuss available treatment modalities that address residual cardiovascular risk in this disease.

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