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. 2010 Sep;18(9):1581-3.
doi: 10.1038/mt.2010.177.

Breathing new life into lung transplantation therapy

Angela Panoskaltsis-Mortari  1 , Daniel J Weiss
Affiliations

Breathing new life into lung transplantation therapy

Angela Panoskaltsis-Mortari et al. Mol Ther. 2010 Sep.
No abstract available

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Figures

Figure 1
Figure 1
Macroscopic images of whole lungs at different stages of decellularization process. (1) Prior to decellularization; (2) after deoxycholate step showing large amounts of white precipitate (probably cellular breakdown material) within the lungs; (3) after the final rinses at the end of the process. Heart is shown still attached at top. Reprinted from ref. .
Figure 2
Figure 2
Implantation of engineered lungs into rats. Tissue-engineered left lung was implanted into adult rat recipient and photographed 30 minutes later. Courtesy of L. Niklason, Yale University.
Figure 3
Figure 3
Orthotopic transplantation and in vivo function. (a) Photograph of left rat chest after left anterior thoracotomy, left pneumonectomy, and orthotopic transplantation of a regenerated left lung construct. Recipient's left pulmonary artery (A), left main bronchus (B), and left pulmonary vein (V) are connected to regenerated left lung pulmonary artery (a), bronchus (b), and pulmonary vein (v). White arrowheads, the recipient's right lung (infracardiac and right lower lobe); black arrowheads, the regenerated left lung construct. (b) Radiograph of rat chest after left pneumonectomy and orthotopic transplantation of a regenerated left lung construct. White arrowheads, recipient's right lung; black arrowheads, regenerated left lung construct. Reprinted from ref. .
See this image and copyright information in PMC

References

    1. Price AP, England KA, Matson AM, Blazar BR., and, Panoskaltsis-Mortari A.2010Development of a decellularized lung bioreactor system for bioengineering the lung: the matrix reloaded Tissue Eng Part Ae-pub ahead of print 26 May 2010. - PMC - PubMed
    1. Cortiella J, Niles J, Cantu A, Brettler A, Pham A, Vargas G, et al. 2010Influence of acellular natural lung matrix on murine embryonic stem cell differentiation and tissue formation Tissue Eng Part Ae-pub ahead of print 21 April 2010. - PubMed
    1. Petersen TH, Calle EA, Zhao L, Lee EJ, Gui L, Raredon MB, et al. 2010Tissue-engineered lungs for in vivo implantation Sciencee-pub ahead of print 28 June 2010. - PMC - PubMed
    1. Ott HC, Clippinger B, Conrad C, Schuetz C, Pomerantseva I, Ikonomou L.et al. (2010Regeneration and orthotopic transplantation of a bioartificial lung Nat Mede-pub ahead of print 13 July 2010. - PubMed
    1. Chapman KR, Mannino DM, Soriano JB, Vermeire PA, Buist AS, Thun MJ, et al. Epidemiology and costs of chronic obstructive pulmonary disease. Eur Respir J. 2006;27:188–207. - PubMed