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. 2009 Fall;20(3):e56-62.
doi: 10.1155/2009/341275.

Prevalence and antimicrobial resistance of diarrheagenic Escherichia coli and Shigella species associated with acute diarrhea in Tehran, Iran

Fereshteh Jafari  1 , Mohammad Hamidian, Maryam Rezadehbashi, Michael Doyle, Siavosh Salmanzadeh-Ahrabi, Faramarz Derakhshan, Mohammad Reza Zali
Affiliations

Prevalence and antimicrobial resistance of diarrheagenic Escherichia coli and Shigella species associated with acute diarrhea in Tehran, Iran

Fereshteh Jafari et al. Can J Infect Dis Med Microbiol. 2009 Fall.

Abstract
in English, French

A study was performed to determine the prevalence and antimicrobial resistance of Shigella species and diarrheagenic Escherichia coli isolates cultured from patients with acute diarrhea in Tehran, Iran. Between May 2003 and May 2005, 1120 diarrheal specimens were collected and assayed for bacterial enteropathogens by conventional and molecular methods. Etiological agents were isolated from 564 (50.3%) specimens, and included 305 (54%) E coli, 157 (27.8%) Shigella species, and 102 (18%) from other genera of bacteria. The predominant E coli was Shiga toxin-producing E coli (105 isolates [34.5%]) and the predominant Shigella serotype was Shigella sonnei (88 isolates [56.1%]). A high rate of antibiotic resistance was observed among E coli, with 40 of 53 (75.5%) Shiga toxin-producing E coli isolates resistant to amoxicillin and tetra-cycline, and eight (5.2%) E coli isolates resistant to more than six antibiotics. Most Shigella isolates were resistant to tetracycline (95%) and trimethoprim-sulfamethoxazole (91.7%), with greatest antibiotic resistance observed among S sonnei (53 of 88 [60.2%] isolates). Antibiotic resistance is widespread in diarrheagenic E coli and Shigella in children with acute diarrhea in Tehran, Iran; hence, updated strategies for appropriate use of antimicrobial agents in Iran are needed.

On a effectué une étude pour déterminer la prévalence et la résistance antimicrobienne des espèces de Shigella et des isolats d’Escherichia coli diarrhéogènes cultivés à partir de prélèvements de patients atteints de diarrhée aiguë à Téhéran, en Iran. Entre mai 2003 et mai 2005, on a prélevé et titré 1 120 échantillons de diarrhée pour dépister des entéropathogènes bactériens au moyen des méthodes classiques et moléculaires. On a isolé des agents étiologiques auprès de 564 échantillons (50,3 %), ce qui incluait 305 cas d’E coli (54 %), 157 espèces de Shigella (27,8 %) et 102 cas d’autres genres de bactéries (18 %). Le principal E coli était un E coli producteur de toxines Shiga (105 isolats [34,5 %]) et le principal sérotype de Shigella, le Shigella sonnei (88 isolats [56,1 %]). On a observé un fort taux d’antibiorésistance dans les cas d’E coli, 40 des 53 cas d’isolats d’E coli producteurs de toxines Shiga (75,5 %) étant résistants à l’amoxicilline et à la tétracycline et huit isolats d’E coli (5,2 %) étant résistants à plus de six antibiotiques. La plupart des isolats de Shigella étaient résistants à la tétracycline (95 %) et au triméthoprim-sulfaméthoxazole (91,7 %), la plus grande antibiorésistance s’observant dans les cas de S sonnei (53 des 88 isolats [60,2 %]). L’antibiorésistance est généralisée en cas d’E coli diarrhéogène et de Shigella chez les enfants atteints de diarrhée aiguë de Téhéran, en Iran. Il faut donc trouver de nouvelles stratégies afin d’utiliser les antimicrobiens convenablement en Iran.

Keywords: Antibiotic resistance; Diarrheagenic pathogens; E coli; Iran; Shigella.

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