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. 2010 Jul:12:073011.
doi: 10.1088/1367-2630/12/7/073011.

Design of an electron microscope phase plate using a focused continuous-wave laser

H Müller  1 , Jian Jin, R Danev, J Spence, H Padmore, R M Glaeser
Affiliations

Design of an electron microscope phase plate using a focused continuous-wave laser

H Müller et al. New J Phys. 2010 Jul.

Abstract

We propose a Zernike phase contrast electron microscope that uses an intense laser focus to convert a phase image into a visible image. We present the relativistic quantum theory of the phase shift caused by the laser-electron interaction, study resonant cavities for enhancing the laser intensity and discuss applications in biology, soft-materials science and atomic and molecular physics.

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Figures

Figure 1
Figure 1
Feynman diagrams for Compton scattering. p1, q, and p2, respectively, denote the initial, intermediate and final momenta of the electron; k1 and k2 are the photon momenta.
Figure 2
Figure 2
(A) The setup for a phase contrast TEM using a near-spherical resonant cavity. The electron beam is propagating orthogonal to the paper plane. (B) Intensity of the TMn01 mode in a spherical cavity. Shown is a two-dimensional contour plot as well as the intensities along the x and y axes through the focus, respectively.
Figure 3
Figure 3
Alternative realizations of laser phase plates. (A) Plano-parabolic cavity; (B) high-NA lens; (C) high-NA lens with retroreflector; (D) two focused, retroreflected beams. The electron beam is propagating orthogonally to the page.
See this image and copyright information in PMC

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References

    1. Glaeser R, Downing K, DeRosier D, Chiu W, Frank J. Electron Crystallography of Biological Macromolecules. Oxford: Oxford University Press; 2007.
    2. Spence JCH. High Resolution Electron Microscopy. New York: Oxford University Press; 2003.
    1. Zernicke F. Physica. 1942;9:686–698.
    2. Zernicke F. Physica. 1942;9:974–986.
    3. Zernicke F. Science. 1955;121:345–349. - PubMed
    1. Boersch H. Z. Nat.forsch. A. 1947;2:615.
    1. Hosokawa F, Danev R, Arai Y, Nagayama K. J. Electron Microsc. 2005;54:317–324. - PubMed
    1. Nagayama K, Danev R. Phil. Trans. R. Soc. B. 2008;363:2153–2162. - PMC - PubMed