Recommendations for visual evaluations of patients treated with vigabatrin

Abstract

Purpose of review: Although vigabatrin has been used for many years in Europe, this antiepileptic medication was approved for use in the USA only 1 year ago because of concerns for irreversible peripheral visual field loss that can result in functional visual disability.

Recent findings: Visual function testing involves both subjective and objective techniques, some of which can be standardized across multiple centers. With these subjective and objectives issues as a reference, the current literature about the pathogenesis of vigabatrin visual toxicity is reviewed in order to develop a practical and reliable testing program for detecting peripheral visual field changes early in their course; thereby, hopefully limiting disabling visual field loss.

Summary: Based upon the existing literature as well as the currently available data about the evaluation of visual function, an algorithm has been developed to serve as a starting point for clinicians to evaluate patients treated with vigabatrin for refractory epilepsy.