Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Sep;12(9):842-6.
doi: 10.1038/ncb0910-842.

Can autophagy promote longevity?

Frank Madeo  1 , Nektarios Tavernarakis, Guido Kroemer
Affiliations

Can autophagy promote longevity?

Frank Madeo et al. Nat Cell Biol. 2010 Sep.

Abstract

Organismal lifespan can be extended by genetic manipulation of cellular processes such as histone acetylation, the insulin/IGF-1 (insulin-like growth factor 1) pathway or the p53 system. Longevity-promoting regimens, including caloric restriction and inhibition of TOR with rapamycin, resveratrol or the natural polyamine spermidine, have been associated with autophagy (a cytoprotective self-digestive process) and in some cases were reported to require autophagy for their effects. We summarize recent developments that outline these links and hypothesize that clearing cellular damage by autophagy is a common denominator of many lifespan-extending manipulations.

PubMed Disclaimer

References

    1. Chem Biol Drug Des. 2009 Dec;74(6):619-24 - PubMed
    1. Cell Death Dis. 2010;1:e10 - PubMed
    1. Autophagy. 2007 Nov-Dec;3(6):597-9 - PubMed
    1. Cancer Res. 2010 Feb 15;70(4):1564-72 - PubMed
    1. Cell Stem Cell. 2009 Sep 4;5(3):279-89 - PubMed

Publication types

MeSH terms

LinkOut - more resources