Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2010 Nov;5(11):1946-53.
doi: 10.2215/CJN.02400310. Epub 2010 Sep 2.

Prevalence of CKD in northeastern Italy: results of the INCIPE study and comparison with NHANES

Giovanni Gambaro  1 , Tewoldemedhn Yabarek, Maria Stella Graziani, Alessandro Gemelli, Cataldo Abaterusso, Anna Chiara Frigo, Nicola Marchionna, Lorenzo Citron, Luciana Bonfante, Francesco Grigoletto, Salvatore Tata, Pietro Manuel Ferraro, Angelo Legnaro, Gina Meneghel, Piero Conz, Paolo Rizzotti, Angela D'Angelo, Antonio Lupo; INCIPE Study Group
Collaborators, Affiliations
Comparative Study

Prevalence of CKD in northeastern Italy: results of the INCIPE study and comparison with NHANES

Giovanni Gambaro et al. Clin J Am Soc Nephrol. 2010 Nov.

Abstract

Background and objectives: Sufficiently powered studies to investigate the CKD prevalence are few and do not cover southern Europe.

Design, setting, participants, & measurements: For the INCIPE study, 6200 Caucasian patients ≥40 years old were randomly selected in northeastern Italy in 2006. Laboratory determinations were centralized. The albumin to creatinine ratio in urine and estimated GFR from calibrated creatinine (SCr) were determined. A comparison with 2001 through 2006 NHANES surveys was performed.

Results: Prevalence of CKD was 13.2% in northeastern (NE) Italy (age and gender standardized to the U.S. 2007 Caucasian population). Prevalence of CKD in U.S. Caucasians is higher (20.3%), the major difference being in CKD 3. Risk factors for CKD are more prevalent in the United States than in Italy. With use of CKD 3a and 3b stages, CKD prevalence decreased in NE Italy (8.5%) and in the United States (12.8%).

Conclusions: The prevalence of CKD is high in NE Italy, but lower than that in the United States. A large part of the difference in CKD prevalence in NE Italy versus that in the United States is due to the different prevalence of CKD 3. The higher prevalence of a number of renal risk factors in persons from the United States explains in part the different dimensions of the CKD problem in the two populations.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Prevalence of CKD according to age classes, in men and women, in INCIPE and NHANES populations.
Figure 2.
Figure 2.
Prevalence of hypertension, metabolic syndrome, obesity, and diabetes according to age classes in INCIPE and NHANES populations.
See this image and copyright information in PMC

References

    1. de Jong PE, van der Velde M, Gansevoort RT, Zoccali C: Screening for chronic kidney disease: Where does Europe go? Clin J Am Soc Nephrol 3: 616–623, 2008 - PMC - PubMed
    1. Coresh J, Astor BC, Green T, Eknoyan G, Levey AS: Prevalence of chronic kidney disease and decreased kidney function in the adult US population. Third National Health and Nutrition Examination Survey. Am J Kidney Dis 41: 1–12, 2003 - PubMed
    1. De Zeeuw D, Hillege HL, de Jong PE: The kidney, a cardiovascular risk marker and a new target for therapy. Kidney Int 68[Suppl 98]: S25–S29, 2005 - PubMed
    1. Hallan SI, Coresh J, Astor BC, Asberg A, Powe NR, Romundstad S, Hallan HA, Lydersen S, Holmen J: International comparison of the relationship of chronic kidney disease prevalence and ESRD risk. J Am Soc Nephrol 17: 2275–2284, 2006 - PubMed
    1. Glassock RJ, Winearls C: An epidemic of chronic kidney disease: Fact or fiction? Nephrol Dial Transplant 23: 1117–1121, 2008 - PubMed

Publication types

MeSH terms