Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2010 Apr;13(2):136-8.
doi: 10.4103/0972-2327.64646.

Idiopathic CD4 lymphocytopenia presenting as refractory cryptococcal meningitis

A Sharma  1 , V Lal, M Modi, D Khurana, S Bal, S Prabhakar
Affiliations
Case Reports

Idiopathic CD4 lymphocytopenia presenting as refractory cryptococcal meningitis

A Sharma et al. Ann Indian Acad Neurol. 2010 Apr.

Abstract

Idiopathic CD4 T-lymphocytopenia (ICL) is a syndrome characterized by depletion of CD4 T-cells without evidence of human immunodeficiency virus (HIV) infection. There are a few reported cases of ICL associated with different diseases and clinical conditions, most commonly the opportunistic infections like Tuberculosis, fungal and parasitic diseases which are also seen in HIV-positive patients. We report a case without risk factors or laboratory evidence of HIV infection who presented with refractory cryptococcal meningitis and was found to have ICL.

Keywords: CD4; Cryptococcus; idiopathic.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: Nil

Figures

Figure 1
Figure 1
MRI brain, axial view, showing T2 hyperintensity in the left thalamus that is extending into the corona radiata
See this image and copyright information in PMC

References

    1. Unexplained CD4 T-lymphocyte depletion in persons without evident HIV infection: United States. MMWR Morb Mortal Wkly Rep. 1992;41:541–5. - PubMed
    1. Global programme on AIDS. Unexplained severe Immunosuppression without evidence of HIV infection. Wkly Epidemiol Rec. 1992;67:309–11. - PubMed
    1. DeHovitz JA, Feldman J, Landesman S. Idiopathic CD4 Lymphocytopenia. N Engl J Med. 1993;329:1045–6. - PubMed
    1. Smith DK, Neal JJ, Holmberg SD. Unexplained opportunistic infections and CD4 T-lymphocytopenia without HIV infection: An investigation of cases in the United States: The Centers for Disease Control Idiopathic CD4 T-lymphocytopenia Task Force. N Engl J Med. 1993;328:373–9. - PubMed
    1. Freier S, Kerem E, Dranitzki Z, Schlesinger M, Rabinowitz R, Brautbar C, et al. Hereditary CD4 T lymphocytopenia. Arch Dis Child. 1998;78:371–2. - PMC - PubMed

Publication types