Dynamics and interactions of glycoconjugates probed by stable-isotope-assisted NMR spectroscopy
- PMID: 20816487
- DOI: 10.1016/S0076-6879(10)78015-0
Dynamics and interactions of glycoconjugates probed by stable-isotope-assisted NMR spectroscopy
Abstract
Unique advantages offered by nuclear magnetic resonance (NMR) spectroscopy provide high-resolution information not only on structures but also on dynamics and interactions of glycoconjugates in solution. These benefits are further enhanced by applying stable-isotope-labeling techniques, which we have developed. Our stable-isotope-assisted NMR analyses of immunoglobulin G-Fc glycoproteins and the glycopeptides derived therefrom are here presented in terms of the dynamics and interactions of glycoconjugates.
Copyright (c) 2010 Elsevier Inc. All rights reserved.
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