Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2011 Feb;125(2-3):247-56.
doi: 10.1016/j.schres.2010.08.006.

A pilot investigation of the Graduated Recovery Intervention Program (GRIP) for first episode psychosis

David L Penn  1 , Sarah R Uzenoff, Diana Perkins, Kim T Mueser, Robert Hamer, Evan Waldheter, Sylvia Saade, Liz Cook
Affiliations
Randomized Controlled Trial

A pilot investigation of the Graduated Recovery Intervention Program (GRIP) for first episode psychosis

David L Penn et al. Schizophr Res. 2011 Feb.

Erratum in

  • Schizophr Res. 2012 Oct;141(1):106-7

Abstract

The Graduated Recovery Intervention Program (GRIP) is a new individual cognitive-behavioral therapy program designed to facilitate functional recovery in people who have experienced an initial episode of psychosis. The purposes of this study were to evaluate the feasibility and tolerability of the GRIP intervention, and to compare the effectiveness of GRIP versus treatment as usual (TAU) for improving specific clinical and psychosocial outcomes. Forty-six individuals with first episode psychosis were randomized to GRIP+TAU or TAU alone. Primary outcomes focused on social and role functioning, and quality of life. Secondary outcomes included psychotic symptoms, depression, substance use, social support, attitudes toward medications, well-being, and hospitalizations. The results indicate that GRIP was well-tolerated, as evidenced by good attendance and low drop-out rates, and well-received (based on positive feedback from participants). Although the majority of mixed model analyses were not statistically significant, examination of within-group changes and effect sizes suggests an advantage for GRIP over TAU in improving functional outcomes. These advantages and the fact that the GRIP intervention demonstrated feasibility and tolerability suggest that this intervention is worthy of further investigation.

PubMed Disclaimer

Figures

Figure 1
Figure 1
GRIP RCT Consort Diagram
See this image and copyright information in PMC

References

    1. Addington D, Addington J, Maticka-Tyndale E. Assessing depression in schizophrenia: The Calgary Depression Scale. British Journal of Psychiatry. 1993;163 Suppl 22:39–44. - PubMed
    1. Addington J, Gleeson J. Implementing cognitive-behavioural therapy for first-episode psychosis. British Journal of Psychiatry. 2005;187 suppl. 48:s72–s76. - PubMed
    1. Birchwood M, Todd P, Jackson C. Early intervention in psychosis: The critical period hypothesis. British Journal of Psychiatry. 1998;172 Suppl. 33:53–59. - PubMed
    1. Dickerson FB, Origoni AE, Pater A, Friedman BK, Kordonski WM. An expanded version of the Multnomah Community Ability Scale: Anchors and interview probes for the assessment of adults with serious mental illness. Community Mental Health Journal. 2003;39(2):131–137. - PubMed
    1. Dolder CR, Lacro JP, Warren KA, Golshan S, Perkins DO, Jeste DV. Brief Evaluation of Medication Influences and Beliefs: Development and Testing of a Brief Scale for Medication Adherence. Journal of Clinical Psychopharmacology. 2004;24(4):404–409. - PubMed

Publication types

MeSH terms