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. 2011 Jan;22(1):47-52.
doi: 10.1007/s00192-010-1245-7. Epub 2010 Sep 7.

Correlation between shrinkage and infection of implanted synthetic meshes using an animal model of mesh infection

Laurent Mamy  1 , Vincent Letouzey, Jean-Philippe Lavigne, Xavier Garric, Jean Gondry, Pierre Mares, Renaud de Tayrac
Affiliations
Free article

Correlation between shrinkage and infection of implanted synthetic meshes using an animal model of mesh infection

Laurent Mamy et al. Int Urogynecol J. 2011 Jan.
Free article

Abstract

Introduction and hypothesis: the aim of this study was to evaluate a link between mesh infection and shrinkage.

Methods: twenty-eight Wistar rats were implanted with synthetic meshes that were either non-absorbable (polypropylene (PP), n = 14) or absorbable (poly (D: ,L: -lactic acid) (PLA94), n = 14). A validated animal incisionnal abdominal hernia model of mesh infection was used. Fourteen meshes (n = 7 PLA94 and n = 7 PP meshes) were infected intraoperatively with 10e6 CFU Escherichia coli, and compared with 14 non-infected meshes (n = 7 PLA94 and n = 7 PP meshes) (control groups). Explantations were performed on day 30. Shrinkage was evaluated by a reproducible numerical analysis of mesh area. Infection and histological study were evaluated on day 30.

Results: non-infected meshes were less shrunk than infected meshes for both non-absorbable (5.0 ± 1.7% versus 21.6 ± 6.1%, p < 0.05) and absorbable meshes (2.4 ± 0.9% versus 11.0 ± 2.5%, p < 0.05).

Conclusion: this study highlights a link between infection and shrinkage in the model used.

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