Mechanisms of fatigue
- PMID: 20822034
Mechanisms of fatigue
Abstract
Fatigue is a common experience of individuals suffering from chronic illnesses. Mechanisms responsible for fatigue may be central or peripheral. Central fatigue may result from proximal events and include the neuromuscular junction and are subdivided into spinal and supraspinal. Peripheral fatigue arises from the muscle and predominately involves muscle bioenergetics or excitation contraction. Fatigue from chronic illnesses can be caused by several mechanisms. Electromyelography, transcranial magnetic stimulation, magnetic resonance imaging, and spectroscopy are helpful tools to clarify the physiologic correlates of fatigue. This state-of-the-art review discusses these physiologic correlates of fatigue and the mechanisms described in a variety of chronic diseases.
Comment in
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Cancer-related fatigue: a multidimensional syndrome.J Support Oncol. 2010 Jul-Aug;8(4):175-6. J Support Oncol. 2010. PMID: 20822035 No abstract available.
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The underrecognized role of impaired muscle function in cancer-related fatigue.J Support Oncol. 2010 Jul-Aug;8(4):177-8. J Support Oncol. 2010. PMID: 20822036 No abstract available.
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