doi: 10.1038/ja.2010.95.
Epub 2010 Sep 8.
Macrolides of the bafilomycin family produced by Streptomyces sp. CS
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- PMID: 20823894
- DOI: 10.1038/ja.2010.95
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Macrolides of the bafilomycin family produced by Streptomyces sp. CS
J Antibiot (Tokyo).
2010 Oct.
Abstract
Five new 16-membered macrolides (1-5), belonging to the bafilomycin subfamily, were isolated from the fermentation broth of Streptomyces sp. CS, a commensal microbe of Maytenus hookeri. Their structures including relative configurations were elucidated based on NMR data and analysis of single crystal X-ray diffraction data. The cytotoxicities of compounds 1-5 on the MDA-MB-435 cell line were analyzed by the MTT method and the IC(50) values were found to be 4.2, 4.5, 5.5, 3.8 and 11.4 μM, respectively.
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