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. 2008;3(s2):16-19.
doi: 10.1159/000151738. Epub 2008 Oct 16.

uPAR and HER2 Genes Are Usually Co-Amplified in Individual Breast Cancer Cells from Blood and Tissues

Jonathan Uhr  1
Affiliations

uPAR and HER2 Genes Are Usually Co-Amplified in Individual Breast Cancer Cells from Blood and Tissues

Jonathan Uhr. Breast Care (Basel). 2008.
No abstract available

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Figures

Fig. 1
Fig. 1
A. Left shows a typical single CTC. As can be seen, the nuclear to cytoplasmic ratio is high, the nucleus frequently has irregularities, and cytokeratin stains the cytoplasm at the periphery of the cell causing a ringlike appearance, all being accepted morphological and immunophenotypical criteria for malignant cells. Center shows uPAR expression by IF in the same CTC. Right shows the results of FISH analysis. The signals can be precisely read on individual CTCs. It is relatively straight-forward to subjectively quantify individual TCs or CTCs into 1-3+ expression as determined above. 1B. shows HER2 gene amplification and expression in representative CTCs, similar to fig. 1A [19].
See this image and copyright information in PMC

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