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. 2010 Aug 31;7(8):e1000322.
doi: 10.1371/journal.pmed.1000322.

Challenges in developing evidence-based recommendations using the GRADE approach: the case of mental, neurological, and substance use disorders

Corrado Barbui  1 , Tarun Dua, Mark van Ommeren, M Taghi Yasamy, Alexandra Fleischmann, Nicolas Clark, Graham Thornicroft, Suzanne Hill, Shekhar Saxena
Affiliations

Challenges in developing evidence-based recommendations using the GRADE approach: the case of mental, neurological, and substance use disorders

Corrado Barbui et al. PLoS Med. .

Abstract

Corrado Barbui and colleagues describe their use and adaptation of the GRADE approach in developing the guidelines for the WHO mental health Gap Action Programme (mhGAP).

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Conflict of interest statement

SH is a member of the GRADE working group on methods for guideline development and currently chairs the WHO Guideline Review Committee that sets standards for WHO guideline development. TD, MvO, MTY, AF, NC, SH, and SS alone are responsible for the views expressed in this publication and they do not necessarily represent the decisions, policy, or views of the World Health Organization.

Figures

Figure 1
Figure 1. Pathway describing the process of recommendation development.
The Guideline Development Group (GDG) developed the scoping documents and the scoping questions. For each scoping question, a WHO working group drafted evidence profiles and profiles incorporating values, preferences, and feasibility considerations. Recommendations were subsequently drafted and submitted to the GDG for review and approval.
Figure 2
Figure 2. From scoping questions to evidence profiles: flow-chart describing the process to identify, summarize, and rate the evidence for each scoping question.
Figure 3
Figure 3. From evidence profiles to recommendations: template describing how evidence, values, preferences, and feasibility issues were considered in making recommendations.
See this image and copyright information in PMC

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