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. 2010 Dec 15;55(5):615-9.
doi: 10.1097/QAI.0b013e3181f4b752.

Association of immunologic and virologic factors with myocardial infarction rates in a US healthcare system

Virginia A Triant  1 , Susan Regan, Hang Lee, Paul E Sax, James B Meigs, Steven K Grinspoon
Affiliations

Association of immunologic and virologic factors with myocardial infarction rates in a US healthcare system

Virginia A Triant et al. J Acquir Immune Defic Syndr. .

Abstract

Background: The effects of immunologic and virologic factors on acute myocardial infarction (AMI) rates in patients with HIV are unclear.

Methods: HIV-infected patients in a US healthcare system were assessed for AMI.

Results: Of 6517 patients with HIV, 273 (4.2%) had an AMI. In a model adjusting for cardiovascular risk factors, antiretroviral medications, and HIV parameters, CD4 count less than 200/mm (odds ratio, 1.74; 95% confidence interval, 1.07 to 2.81; P = 0.02) predicted AMI. Increased HIV viral load was associated with AMI accounting for cardiovascular disease risk factors and antiretroviral medications but was not significant when CD4 count was considered.

Conclusions: Immunologic control appears to be the most important HIV-related factor associated with AMI.

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Figures

Figure 1
Figure 1
Odds Ratio for AMI in a Multivariate Analysis Odds ratios and 95% confidence intervals are shown for each cardiovascular risk factor with respect to AMI risk. The odds ratios for all covariates in the model are shown. Medications were included in the model if they were significantly associated with AMI in univariate analyses. Age is represented in 10 year increments. ABC indicates abacavir; DDI, didanosine; FTC, emtricitabine; D4T, stavudine; TDF, tenofovir; NVP, nevirapine; ATV, atazanavir; NFV, nelfinavir; SQV, saquinavir; ART, antiretroviral therapy.
See this image and copyright information in PMC

References

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