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. 2010 Apr 9;4(2):523-9.
doi: 10.1007/s12072-010-9181-7.

Risk factors, genotype 6 prevalence, and clinical characteristics of chronic hepatitis C in Southeast Asian Americans

Nghia H Nguyen, Philip Vutien, Huy N Trinh, Ruel T Garcia, Long H Nguyen, Huy A Nguyen, Khanh K Nguyen, Mindie H Nguyen

Risk factors, genotype 6 prevalence, and clinical characteristics of chronic hepatitis C in Southeast Asian Americans

Nghia H Nguyen et al. Hepatol Int. .

Abstract

Purpose: Although infection with hepatitis C virus (HCV) affects 32 million individuals from Southeast Asia, little is known about the mode of HCV acquisition and the epidemiology of chronic hepatitis C (CHC) in these individuals. Our goal was to examine risk factors for HCV acquisition, prevalence, and clinical characteristics of HCV genotype 6 compared with genotypes 1 and 2/3 in Southeast Asian (SEA) patients.

Methods: We performed a cross-sectional study of 308 consecutive SEA Americans with CHC evaluated by five gastroenterologists from January 2000 to December 2008 at two community clinics in northern California via medical record review, using a case report form.

Results: A significant proportion of patients (41%) could not recall any specific risk factors for HCV acquisition. The most commonly reported risk factor in patients who reported at least one risk factor was history of surgeries (34%), followed by blood transfusion (25%) and acupuncture (13%). Among patients with core sequence testing for HCV genotype (n = 181), the most common HCV genotypes were genotype 1 (42%) and genotype 6 (41%), followed by genotype 2/3 (17%). There were no major differences in the clinical and virological characteristics between the different genotype groups (1 vs. 2/3 vs. 6).

Conclusion: HCV genotype 6 is as common as genotype 1 in SEAs. Commonly known risk factors for HCV acquisition were not readily identifiable in a large proportion of SEA Americans (41%) and may not be useful in identifying at-risk individuals for HCV screening in this population.

Keywords: Epidemiology; Genotype 6; HCV; Risk factors; Southeast Asians.

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Figures

Fig. 1
Fig. 1
Exposure risks for infection with hepatitis C virus
Fig. 2
Fig. 2
Exposure risks for infection with hepatitis C virus in Southeast Asians by core sequencing assay
Fig. 3
Fig. 3
Hepatitis C genotypes in Southeast Asians by core sequencing assay
Fig. 4
Fig. 4
Hepatitis C genotypes in Southeast Asians by INNO-LiPA assay
See this image and copyright information in PMC

References

    1. Hepatitis C—global prevalence (update). Wkly Epidemiol Rec 1999;74(49):425–427 - PubMed
    1. Mallette C, Flynn MA, Promrat K. Outcome of screening for hepatitis C virus infection based on risk factors. Am J Gastroenterol. 2008;103(1):131–137. - PubMed
    1. El-Serag HB. Hepatocellular carcinoma and hepatitis C in the United States. Hepatology. 2002;36(5 Suppl 1):S74–S83. doi: 10.1002/hep.1840360710. - DOI - PubMed
    1. Hassan MM, Frome A, Patt YZ, El-Serag HB. Rising prevalence of hepatitis C virus infection among patients recently diagnosed with hepatocellular carcinoma in the United States. J Clin Gastroenterol. 2002;35(3):266–269. doi: 10.1097/00004836-200209000-00013. - DOI - PubMed
    1. Armstrong GL, Wasley A, Simard EP, McQuillan GM, Kuhnert WL, Alter MJ. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med. 2006;144(10):705–714. - PubMed

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