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Comparative Study
. 2011 Mar 15;95(4):1467-70.
doi: 10.1016/j.fertnstert.2010.08.001. Epub 2010 Sep 9.

Effect of bilateral oophorectomy on wound healing of the rabbit vagina

Yoram Abramov  1 , Antonio R Webb, Sylvia M Botros, Roger P Goldberg, Guillermo A Ameer, Peter K Sand
Affiliations
Comparative Study

Effect of bilateral oophorectomy on wound healing of the rabbit vagina

Yoram Abramov et al. Fertil Steril. .

Abstract

We aimed to assess the effect of bilateral oophorectomy on vaginal wound healing in three groups of New Zealand White rabbits (24 rabbits each). Group 1 underwent bilateral oophorectomy, group 2 underwent a sham surgery, and group 3 served as control. Standardized vaginal tissue specimens were harvested and assessed for wound and scar surface area and tensiometric analysis before wounding, and sequentially thereafter, showing that vaginal wound closure, scar contraction, and recovery of biomechanical properties are significantly slower in oophorectomized rabbits.

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