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Review
. 2010 Sep;25(3):227-36.
doi: 10.3904/kjim.2010.25.3.227. Epub 2010 Aug 31.

Non-gastric marginal zone B-cell lymphoma in Korea: clinical features, treatment, and prognostic factors

Sung Yong Oh  1 , Cheolwon Suh
Affiliations
Review

Non-gastric marginal zone B-cell lymphoma in Korea: clinical features, treatment, and prognostic factors

Sung Yong Oh et al. Korean J Intern Med. 2010 Sep.

Abstract

Marginal zone B-cell lymphoma (MZL) is the second most common subtype of non-Hodgkin's lymphoma in Korea (17.3%). Mucosa-associated lymphoid tissue (MALT) can develop in almost any organ as a result of exposure to a persistent stimulus, such as chronic infection or certain autoimmune processes. Under conditions of prolonged lymphoid proliferation, a malignant clone may emerge, which is followed by the development of a MALT lymphoma. Whereas MALT lymphoma of the stomach is the most common and the most extensively studied, we focus on non-gastric MZL studies conducted in Korea that highlight the most recent advances with respect to MZL definition, etiology, clinical characteristics, natural history, treatment approaches, outcomes, and prognostic factors. Moreover, we discuss current organ-specific considerations and controversies, and identify areas for future research.

Keywords: Korea; Lymphoma, B-cell, marginal zone.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

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