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Clinical Trial
. 1990;30(3-4):351-65.

Treatment of severe hyaline membrane disease with surfactant (Curosurf). A collaborative clinical study

B Büky  1 , G Dévai, E Várady, A Rózsavölgyi, I Kovách, A Kovács, G Jancsó, K Waldinger, A Görgényi, B Zsolnai, et al.
Affiliations
  • PMID: 2083097
Clinical Trial

Treatment of severe hyaline membrane disease with surfactant (Curosurf). A collaborative clinical study

B Büky et al. Acta Paediatr Hung. 1990.

Abstract

We investigated the clinical efficacy of a new surfactant product, Curosurf, isolated from porcine lungs by liquid-gel chromatography. Ten premature newborn infants (birth weight 850-1850 g), all ventilated artificially for severe hyaline membrane disease categorized radiologically as stage III-IV, received a single dose of Curosurf (200 mg/kg) via the tracheal tube. This treatment resulted in a rapid improvement of oxygenation, similar to that observed by other teams collaborating in the study and, in an astonishingly fast resolution of the radiological changes. In comparison with a control group of 8 infants, the surfactant-treated babies also had a lower incidence of acute and chronic complications.

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