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. 2011 Feb;201(2):186-91.
doi: 10.1016/j.amjsurg.2010.01.030. Epub 2010 Sep 15.

Significance of modified Glasgow prognostic score as a useful indicator for prognosis of patients with gastric carcinoma

Tadahiro Nozoe  1 , Tomohiro Iguchi, Akinori Egashira, Eisuke Adachi, Akito Matsukuma, Takahiro Ezaki
Affiliations

Significance of modified Glasgow prognostic score as a useful indicator for prognosis of patients with gastric carcinoma

Tadahiro Nozoe et al. Am J Surg. 2011 Feb.

Abstract

Background: The significance of the Glasgow prognostic score (GPS), an inflammation-based prognostic score, as an indicator of aggressiveness in gastric carcinoma has not been investigated fully.

Methods: Two hundred thirty-two patients with gastric carcinoma were enrolled. Patients who had both an elevated C-reactive protein (>1.0 mg/dL) and hypoalbuminemia (<3.5 g/dL) were allocated a traditional GPS (TGPS) of 2. Patients who had one of these abnormal values were allocated a TGPS of 1, and patients who had neither were allocated a TGPS of 0.

Results: There existed a significant difference between the survival of adjacent groups of patients when examined using the TGPS (P = .05 for TGPS 0 vs 1 and P = .006 for TGPS 1 vs 2). Multivariate analysis based on TGPS demonstrated that TGPS (P = .020) and tumor stage (P = .0007) proved to be independent prognostic indicators for worse prognosis.

Conclusions: The preoperative measurement of an inflammation-based prognostic score can demonstrate a strict stratification for the prognosis of patients with gastric carcinoma.

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