Review
Multicomponent transcription factor complexes: the exception or the rule?
Affiliations
- PMID: 2083246
Item in Clipboard
Review
Multicomponent transcription factor complexes: the exception or the rule?
New Biol.
1990 Feb.
Abstract
Several functionally defined transcription factors have been described to lack the capacity for direct DNA binding. They are guided to their sites of function in promoter complexes by specific interactions with DNA- binding factors. This review explores both the phenomenon of binding dependence and the role of non-DNA-binding auxiliary factors in the context of several eukaryotic gene regulatory systems. The growing number of examples of multicomponent transcription factor complexes suggests that such additional levels of protein interaction and inferred control may be ubiquitous rather than exotic.
Similar articles
-
FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements.Oncogene. 1997 Jan 16;14(2):213-21. doi: 10.1038/sj.onc.1200839. Oncogene. 1997. PMID: 9010223
-
Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct interactions with basal transcription factors.Mol Pharmacol. 1996 Sep;50(3):538-48. Mol Pharmacol. 1996. PMID: 8794892
-
Interaction of Ap1, Ap2, and Sp1 with the regulatory regions of the human pro-alpha1(I) collagen gene.Arch Biochem Biophys. 2000 May 1;377(1):69-79. doi: 10.1006/abbi.2000.1760. Arch Biochem Biophys. 2000. PMID: 10775443
-
PU.1/Interferon Regulatory Factor interactions: mechanisms of transcriptional regulation.Cell Biochem Biophys. 2000;33(2):127-48. doi: 10.1385/CBB:33:2:127. Cell Biochem Biophys. 2000. PMID: 11325034 Review.
-
The virtuoso of versatility: POU proteins that flex to fit.J Mol Biol. 2000 Oct 6;302(5):1023-39. doi: 10.1006/jmbi.2000.4107. J Mol Biol. 2000. PMID: 11183772 Review.
Cited by
-
Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene.Mol Cell Biol. 1991 Oct;11(10):5147-53. doi: 10.1128/mcb.11.10.5147-5153.1991. Mol Cell Biol. 1991. PMID: 1833631 Free PMC article.
-
An NF kappa B-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription.Nucleic Acids Res. 1991 May 25;19(10):2645-53. doi: 10.1093/nar/19.10.2645. Nucleic Acids Res. 1991. PMID: 1710341 Free PMC article.
-
LEF-1 contains an activation domain that stimulates transcription only in a specific context of factor-binding sites.EMBO J. 1993 Dec;12(12):4667-76. doi: 10.1002/j.1460-2075.1993.tb06155.x. EMBO J. 1993. PMID: 8223476 Free PMC article.
-
Negative regulation of the BZLF1 promoter of Epstein-Barr virus.J Virol. 1991 Jul;65(7):3647-55. doi: 10.1128/JVI.65.7.3647-3655.1991. J Virol. 1991. PMID: 1645787 Free PMC article.
-
Cell-type specific multiprotein complex formation over the c-fos serum response element in vivo: ternary complex formation is not required for the induction of c-fos.Nucleic Acids Res. 1991 Jul 11;19(13):3607-11. doi: 10.1093/nar/19.13.3607. Nucleic Acids Res. 1991. PMID: 1906604 Free PMC article.