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Review
. 2010 Dec;12(14-15):1144-52.
doi: 10.1016/j.micinf.2010.08.012. Epub 2010 Sep 9.

The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics

Jia Liu  1 , Sonia Wennier, Grant McFadden
Affiliations
Review

The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics

Jia Liu et al. Microbes Infect. 2010 Dec.

Abstract

Myxoma virus (MYXV) is a poxvirus with a strict rabbit-specific host-tropism for pathogenesis. The immunoregulatory factors encoded by MYXV can suppress some functions of immune effectors from other species. We review their mechanisms of action, implications in therapeutics and the potential to improve MYXV as an oncolytic agent in humans.

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