A cellular view of Nf2 in liver homeostasis and tumorigenesis
- PMID: 20833359
- DOI: 10.1016/j.devcel.2010.08.015
A cellular view of Nf2 in liver homeostasis and tumorigenesis
Abstract
How liver adjusts and stabilizes its size is unsolved so far; the answers to this question may also provide insights into mechanisms of hepatocarcinogenesis. Two recent papers suggest a role for Merlin/Nf2 in control of liver cell turnover, but results appear conflicting at first glance.
Copyright © 2010 Elsevier Inc. All rights reserved.
Comment on
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The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals.Dev Cell. 2010 Jul 20;19(1):27-38. doi: 10.1016/j.devcel.2010.06.015. Dev Cell. 2010. PMID: 20643348 Free PMC article.
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Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver.Genes Dev. 2010 Aug 15;24(16):1718-30. doi: 10.1101/gad.1938710. Epub 2010 Jul 30. Genes Dev. 2010. PMID: 20675406 Free PMC article.
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