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Randomized Controlled Trial
. 2010 Dec;20(12):907-12.
doi: 10.1016/j.euroneuro.2010.08.003. Epub 2010 Sep 15.

Effects on cognitive functioning after olanzapine-ziprasidone crossover in recent-onset schizophrenia

K P Grootens  1 , N M J van Veelen, M M Sitskoorn, B G C Sabbe, J Peuskens, J K Buitelaar, R J Verkes, R S Kahn
Affiliations
Randomized Controlled Trial

Effects on cognitive functioning after olanzapine-ziprasidone crossover in recent-onset schizophrenia

K P Grootens et al. Eur Neuropsychopharmacol. 2010 Dec.

Abstract

Introduction: To enhance functional outcome in schizophrenia improvement of cognitive symptoms is crucial.

Experimental procedures: Using a comprehensive test battery, this follow-up examines cognitive effects in patients with recent-onset schizophrenia after a change of medication following insufficient clinical response and intolerance.

Results: After eight weeks cognitive outcomes had not improved in the patients having switched from olanzapine to ziprasidone (n=11; mean dose 136 mg) nor in those having switched from ziprasidone to olanzapine (n=10; mean 16 mg), while the symptoms of patients maintaining olanzapine (n=18; mean 10.9 mg) or ziprasidone (n=18; mean 88.9 mg) treatment had not improved further.

Discussion: The findings suggest that also in early-stage schizophrenia the antipsychotics tested affect cognitive symptoms similarly.

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