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. 2010;74(9):1969-71.
doi: 10.1271/bbb.100362. Epub 2010 Sep 7.

Protease-catalyzed monoacylation of 2-O-α-D-glucopyranosyl-L-ascorbic acid in three solvent systems

Akihiro Tai  1 , Yuji Iwaoka, Tasuku Mori, Hideyuki Ito
Affiliations
Free article

Protease-catalyzed monoacylation of 2-O-α-D-glucopyranosyl-L-ascorbic acid in three solvent systems

Akihiro Tai et al. Biosci Biotechnol Biochem. 2010.
Free article

Abstract

6-O-dodecanoyl-2-O-α-D-glucopyranosyl-L-ascorbic acid (6-sDode-AA-2G) was synthesized from 2-O-α-D-glucopyranosyl-L-ascorbic acid and vinyl laurate with a protease from Bacillus subtilis in 30% dimethylformamide (DMF)/dioxane with a low water content. The addition of 3% (v/v) water to DMF/dioxane dramatically enhanced the 6-sDode-AA-2G synthesis. The optimum reaction conditions enabled 6-sDode-AA-2G to be synthesized in a yield of 38.1%.

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