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. 2010 Sep;29(5):471-6.
doi: 10.1037/a0020594.

5-HTTLPR status moderates the effect of early adolescent substance use on risky sexual behavior

Steven M Kogan  1 , Steven R H Beach, Robert A Philibert, Gene H Brody, Yi-Fu Chen, Man-Kit Lei
Affiliations

5-HTTLPR status moderates the effect of early adolescent substance use on risky sexual behavior

Steven M Kogan et al. Health Psychol. 2010 Sep.

Abstract

Objective: A longitudinal, prospective design was used to investigate a moderation effect in the association between early adolescent substance use and risky sexual behavior 2 years later. A genetic vulnerability factor, a variable nucleotide repeat polymorphism (VNTR) in the promoter region of the serotonin transporter gene SLC6A4, known as 5-HTTLPR, was hypothesized to moderate the link between substance use at age 14 and risky sexual behavior at age 16. This VNTR has been associated with risk-taking behavior.

Design: African American youths in rural Georgia (N = 185) provided 2 waves of data on their substance use and sexual behavior. Genetic data were obtained via saliva samples.

Main outcome measures: Substance use and sexual risk behavior were assessed using youth self-report items developed for this investigation.

Results: Multiple regression analyses indicated that the presence of 1 or 2 copies of the short allele of the VNTR interacted with substance use to predict sexual behavior. Substance use had little effect on sexual behavior for youths without the short allele; this effect was greatly increased for youths with the short allele.

Conclusion: Genetic vulnerability affected the implications of early onset substance use for later sexual behavior.

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Figures

Figure 1
Figure 1
5-HTTLPR status (presence vs. absence of a short allele) moderates the association between substance use and risky sexual behavior.
See this image and copyright information in PMC

References

    1. Auerbach JG, Faroy M, Ebstein R, Kahana M, Levine J. The association of the dopamine D4 receptor gene (DRD4) and the serotonin transporter promoter gene (5-HTTLPR) with temperament in 12-month-old infants. Journal of Child Psychology and Psychiatry. 2001;42:777–783. doi: 10.1111/1469-7610.00774. - DOI - PubMed
    1. Badawy AAB. Alcohol, aggression and serotonin: Metabolic aspects. Alcohol and Alcoholism. 1998;33:66–72. doi: 10.1093/alcalc/33.6.616. - DOI - PubMed
    1. Bennett AJ, Lesch KP, Heils A, Long JC, Lorenz JG, Shoaf SE, Higley JD. Early experience and serotonin transporter gene variation interact to influence primate CNS function. Molecular Psychiatry. 2002;7:118–122. doi: 10.1038/sj/mp/4000949. - DOI - PubMed
    1. Bradley SL, Dodelzon K, Sandhu HK, Philibert RA. Relationship of serotonin transporter gene polymorphisms and haplotypes to mRNA transcription. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2005;136B:58–61. doi: 10.1002/ajmg.b.30185. - DOI - PubMed
    1. Bricker JB, Stallings MC, Corley RP, Wadsworth SJ, Bryan A, Timberlake DS, DeFries JC. Genetic and environmental influences on age at sexual initiation in the Colorado Adoption Project. Behavior Genetics. 2006;36:820–832. doi: 10.1007/s10519-006-9079-2. - DOI - PubMed

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