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Review
. 2010:658:3-17.
doi: 10.1007/978-1-60761-780-8_1.

Approaches and applications of quantitative LC-MS for proteomics and activitomics

Pedro R Cutillas  1 , John F Timms
Affiliations
Review

Approaches and applications of quantitative LC-MS for proteomics and activitomics

Pedro R Cutillas et al. Methods Mol Biol. 2010.

Abstract

LC-MS is a powerful technique in biomolecular research. In addition to its uses as a tool for protein and peptide quantization, LC-MS can also be used to quantify the activity of signalling and metabolic pathways in a multiplex and comprehensive manner, i.e. as an 'activitomic' tool. Taking cancer research as an illustrative example of application, this review discusses the concepts of biochemical pathway analysis using LC-MS-based proteomic and activitomic techniques.

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