Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Dec;55(4):503-9.
doi: 10.1097/QAI.0b013e3181f5379a.

Antiretroviral therapy outcomes of HIV-infected children in the TREAT Asia pediatric HIV observational database

Rawiwan Hansudewechakul  1 , Virat Sirisanthana, Nia Kurniati, Thanyawee Puthanakit, Pagakrong Lumbiganon, Vonthanak Saphonn, Nik Khairulddin Nik Yusoff, Nagalingeswaran Kumarasamy, Siew Moy Fong, Revathy Nallusamy, Preeyaporn Srasuebkul, Matthew Law, Annette H Sohn, Kulkanya Chokephaibulkit; TREAT Asia Pediatric HIV Observational Database
Collaborators, Affiliations

Antiretroviral therapy outcomes of HIV-infected children in the TREAT Asia pediatric HIV observational database

Rawiwan Hansudewechakul et al. J Acquir Immune Defic Syndr. 2010 Dec.

Abstract

Introduction: We report responses to combination antiretroviral therapy (cART) in the Therapeutics Research, Education, and AIDS Training in Asia Pediatric HIV Observational Database.

Methods: Children included were those who had received cART (ie, ≥3 antiretrovirals) at <18 years. The analysis was intention-to-treat by the first cART regimen. Median values are provided with interquartile ranges; hazard ratios (HRs) with 95% confidence intervals.

Results: Of the 1655 children included, 50.4% were male, with a median age at cART of 7.0 (3.9-9.8) years and CD4 of 8% (2.0%-15%); 92.5% were started on an NNRTI; median duration of follow-up was 2.9 (1.4-4.6) years. Loss-to-follow-up and death rates were 4.2 (3.7-4.8) and 2.1 (1.7-2.5) per 100 person-years, respectively. At 36 months, median CD4 was 26% (21%-31%); 81% of those with viral load (n = 302) were <400 copies per milliliter. Children who reached CD4 ≥25% within 5 years were more likely to be females (HR: 1.4; 1.2-1.7), start before 18 months old (HR: 3.8; 2.4-6.2), lack a history of monotherapy/dual therapy (HR: 1.7; 1.4-2.5), and have a higher baseline CD4 (per 10% increase: HR: 2; 1.9-2.2).

Conclusions: These data underscore the need for early diagnosis and cART initiation to preserve immune function.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Time to death and loss to follow-up after cART initiation
Abbreviation: LTFU-loss to follow-up; cART-combination antiretroviral therapy.
Figure 2
Figure 2. Growth recovery after cART as assessed by median weight-for-age and height-for-age z scores
Abbreviations: HAZ-height for age z score; WAZ-weight for age z score; cART-combination antiretroviral therapy.
Figure 3
Figure 3. Time to CD4 recovery to ≥25% after cART initiation, by baseline CD4% (A) and by age at cART initiation (B)
Abbreviation: cART-combination antiretroviral therapy.
Figure 3
Figure 3. Time to CD4 recovery to ≥25% after cART initiation, by baseline CD4% (A) and by age at cART initiation (B)
Abbreviation: cART-combination antiretroviral therapy.
See this image and copyright information in PMC

References

    1. UNAIDS, WHO. AIDS Epidemic Update: December 2009. Geneva: 2009.
    1. UNICEF. Children and AIDS, Fourth stocktaking report. 2009.
    1. WHO. Antiretroviral therapy of HIV infection in infants and children in resource-limited settings: Towards universal access, Recommendations for a public-health approach. 2006. - PubMed
    1. Violari A, Cotton MF, Gibb DM, et al. Early antiretroviral therapy and mortality among HIV-infected infants. N Engl J Med. 2008 Nov 20;359(21):2233–2244. - PMC - PubMed
    1. Kariminia A, Chokephaibulkit K, Pang J, et al. Cohort Profile: The TREAT Asia Pediatric HIV Observational Database. Int J Epidemiol. 2010 - PMC - PubMed

Publication types

Substances