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. 2010 Nov 15;25(15):2587-94.
doi: 10.1002/mds.23361.

Familial aggregation of Parkinson's disease in a multiethnic community-based case-control study

Michael Y Shino  1 , Valerie McGuire, Stephen K Van Den Eeden, Caroline M Tanner, Rita Popat, Amethyst Leimpeter, Allan L Bernstein, Lorene M Nelson
Affiliations

Familial aggregation of Parkinson's disease in a multiethnic community-based case-control study

Michael Y Shino et al. Mov Disord. .

Abstract

To assess the familial aggregation of Parkinson's disease (PD), we compared the cumulative incidence of PD among first-degree relatives of PD cases and controls. We identified newly diagnosed patients with PD (n = 573) during 1994 to 1995 within Kaiser Permanente Medical Care Program of Northern California and recruited 496 cases (87%) for the case-control study. Of 720 eligible controls matched by birth year and sex to cases, 541 (75%) agreed to participate. Information on family history of PD and other neurodegenerative diseases was obtained by in-person structured interview. We used the reconstructed cohort approach that provides a better estimate of the risk. The cumulative incidence of PD was significantly higher among relatives of PD patients compared with relatives of controls (2.0 vs. 0.7%; relative risk (RR) = 3.4, 95% confidence interval (CI) 1.9-5.9; P = 0.0001). The degree of familial aggregation was higher among first-degree relatives of Hispanic PD cases compared with Hispanic controls (3.7% vs. 0.4%; RR = 8.5, 95% CI 1.0-68.9) than it was among non-Hispanic Caucasian cases and controls (2.0% vs. 0.8%; RR = 2.7, 95% CI 1.5-5.1; P = 0.02). The familial aggregation of PD was stronger among the siblings of PD cases (RR = 5.4, 95% CI 1.8-16.0) than among parents (RR = 2.7, 95% CI 1.3-5.2). The incidence and familial aggregation of PD is highest among Hispanics, warranting further studies of genetic and environmental risk factors in the Hispanic population.

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Conflict of interest statement

FINANCIAL DISCLOSURE/CONFLICT OF INTEREST FOR THIS STUDY

Drs. Shino, McGuire, Van Den Eeden, Tanner, Popat, Bernstein, Nelson and Ms. Leimpeter have no financial disclosures.

Figures

Figure 1
Figure 1
Cumulative incidence of Parkinson’s disease in first-degree relatives of PD cases and controls, (a) all relatives, (b) by sex of proband, and (c) by relationship to proband, Kaiser Permanente Medical Care Program (KPMPC) of Northern California, 1994–1995. Person-years is thesum of the time that each individual was under observation and remained free of disease.
Figure 1
Figure 1
Cumulative incidence of Parkinson’s disease in first-degree relatives of PD cases and controls, (a) all relatives, (b) by sex of proband, and (c) by relationship to proband, Kaiser Permanente Medical Care Program (KPMPC) of Northern California, 1994–1995. Person-years is thesum of the time that each individual was under observation and remained free of disease.
Figure 1
Figure 1
Cumulative incidence of Parkinson’s disease in first-degree relatives of PD cases and controls, (a) all relatives, (b) by sex of proband, and (c) by relationship to proband, Kaiser Permanente Medical Care Program (KPMPC) of Northern California, 1994–1995. Person-years is thesum of the time that each individual was under observation and remained free of disease.
See this image and copyright information in PMC

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