Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1990 Nov 9;68(21):1066-70.
doi: 10.1007/BF01649307.

[Autoantibodies against the complement component C1q in systemic lupus erythematosus]

[Article in German]
U Antes  1 , H P Heinz, K Hartung, M Loos
Affiliations
Clinical Trial

[Autoantibodies against the complement component C1q in systemic lupus erythematosus]

[Article in German]
U Antes et al. Klin Wochenschr. .

Abstract

Autoantibodies against C1q, a subcomponent of the first complement component C1, could be detected in 49.4% of sera from patients with systemic lupus erythematosus (SLE). They are directed against the collagen-like portion of the C1q molecule and recognize only bound, but not fluid-phase C1q. The appearance of these autoantibodies in the course of SLE correlates with the detection of IgG in the C1q-Solid-Phase-Binding-assay, with high titres of dsDNA-antibodies and with depressed total complement activity (CH50) and C1q-values. Our investigations show that autoantibodies against the collagen-like portion of bound C1q but not immune complexes are the main constituent of C1q-binding IgG in SLE.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. J Exp Med. 1971 Sep 1;134(3 Pt 2):228s-241s - PubMed
    1. Adv Immunol. 1982;33:167-240 - PubMed
    1. Clin Immunol Immunopathol. 1987 Mar;42(3):338-43 - PubMed
    1. J Immunol. 1980 Mar;124(3):1251-7 - PubMed

MeSH terms

LinkOut - more resources