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Clinical Trial
. 1990 Nov 9;68(21):1066-70.
doi: 10.1007/BF01649307.

[Autoantibodies against the complement component C1q in systemic lupus erythematosus]

[Article in German]
U Antes  1 , H P Heinz, K Hartung, M Loos
Affiliations
Clinical Trial

[Autoantibodies against the complement component C1q in systemic lupus erythematosus]

[Article in German]
U Antes et al. Klin Wochenschr. .

Abstract

Autoantibodies against C1q, a subcomponent of the first complement component C1, could be detected in 49.4% of sera from patients with systemic lupus erythematosus (SLE). They are directed against the collagen-like portion of the C1q molecule and recognize only bound, but not fluid-phase C1q. The appearance of these autoantibodies in the course of SLE correlates with the detection of IgG in the C1q-Solid-Phase-Binding-assay, with high titres of dsDNA-antibodies and with depressed total complement activity (CH50) and C1q-values. Our investigations show that autoantibodies against the collagen-like portion of bound C1q but not immune complexes are the main constituent of C1q-binding IgG in SLE.

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