Review
Hydrophilic interaction liquid chromatography-tandem mass spectrometry for drug development
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- PMID: 20843291
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Review
Hydrophilic interaction liquid chromatography-tandem mass spectrometry for drug development
Curr Drug Discov Technol.
2010 Sep.
Abstract
Hydrophilic interaction chromatography (HILIC) offers a difference in selectivity as compared to traditional normal phase and reversed-phase liquid chromatography and therefore has great potential for the separation of a variety of pharmaceuticals. This review is devoted to summarizing HILIC coupled to tandem mass spectrometric (MS/MS) methods for the rapid, sensitive and accurate determinations of small molecules employed for supporting drug discovery. The perspectives and challenges on performing HILIC-MS/MS assays are also presented.
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