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. 2010 Oct 15;12(20):4628-31.
doi: 10.1021/ol101890t.

Synthesis of the indolizino[7,6-c]quinoline alkaloid isaindigotidione

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Synthesis of the indolizino[7,6-c]quinoline alkaloid isaindigotidione

Malik Hellal et al. Org Lett. .

Abstract

The first synthesis of isaindigotidione has been developed utilizing a reaction sequence including an asymmetric rhodium-catalyzed 1,4-conjugate addition, an intramolecular aldol reaction, and a lactamization.

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