Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Oct 15;202 Suppl 2(Suppl 2):S278-88.
doi: 10.1086/655655.

Clinical management of acute HIV infection: best practice remains unknown

Sigall K Bell  1 , Susan J Little, Eric S Rosenberg
Affiliations
Review

Clinical management of acute HIV infection: best practice remains unknown

Sigall K Bell et al. J Infect Dis. .

Abstract

Best practice for the clinical management of acute human immunodeficiency virus (HIV) infection remains unknown. Although some data suggest possible immunologic, virologic, or clinical benefit of early treatment, other studies show no difference in these outcomes over time, after early treatment is discontinued. The literature on acute HIV infection is predominantly small nonrandomized studies, which further limits interpretation. As a result, the physician is left to grapple with these uncertainties while making clinical decisions for patients with acute HIV infection. Here we review the literature, focusing on the potential advantages and disadvantages of treating acute HIV infection outlined in treatment guidelines, and summarize the presentations on clinical management of acute HIV infection from the 2009 Acute HIV Infection Meeting in Boston, Massachusetts.

PubMed Disclaimer

Conflict of interest statement

Potential conflicts of interest: S.K.B. reports no conflict.

Comment in

References

    1. Department of Health and Human Services Panel on Antiretroviral Guidelines for Adults and Adolescents, a working group of the Office of AIDS Research Advisory Council. Guidelines for the use of anti-retroviral agents in HIV-1-infected adults and adolescents. http://aidsinfo.nih.gov/contentfiles/AdultandAdolescentGL.pdf. 2009. Accessed 3 December 2009.
    1. Kinloch-De Loes S, Hirschel BJ, Hoen B, et al. A controlled trial of zidovudine in primary human immunodeficiency virus infection. N Engl J Med. 1995;333:408–413. - PubMed
    1. Niu MT, Bethel J, Holodniy M, Standiford HC, Schnittman SM, for the DATRI 002 Study Group, Division of AIDS Treatment Research Initiative Zidovudine treatment in patients with primary (acute) human immunodeficiency virus type 1 infection: a randomized, double-blind, placebo-controlled trial. J Infect Dis. 1998;178:80–91. - PubMed
    1. Zala C, Salomon H, Ochoa C, et al. Higher rate of toxicity with no increased efficacy when hydroxyurea is added to a regimen of stavudine plus didanosine and nevirapine in primary HIV infection. J Acquir Immune Defic Syndr. 2002;29:368–373. - PubMed
    1. Dybul M, Hidalgo B, Chun TW, et al. Pilot study of the effects of intermittent interleukin-2 on human immunodeficiency virus (HIV)-specific immune responses in patients treated during recently acquired HIV infection. J Infect Dis. 2002;185:61–68. - PubMed

Publication types

Substances