Comparative study between oral and sublingual 600 µg misoprostol for the treatment of incomplete abortion
- PMID: 20846257
- DOI: 10.1111/j.1447-0756.2010.01264.x
Comparative study between oral and sublingual 600 µg misoprostol for the treatment of incomplete abortion
Abstract
Aim: To evaluate and compare effectiveness, side effects and patient acceptability between oral and sublingual 600 µg misoprostol for the treatment of incomplete abortion.
Methods: A randomized controlled trial was conducted. Pregnant women of less than 14 weeks gestation, diagnosed with incomplete abortion, were randomly assigned to receive 600 µg misoprostol orally or sublingually. The patients were evaluated at 48 h after drug administration for complete abortion.
Results: A total of 64 women were recruited to the study (32 in the oral group and 32 in the sublingual group). The complete abortion rate was not statistically different between oral and sublingual groups (87.5% versus 84.4%, P > 0.05). There was no statistical difference in side effects and satisfaction rate. Fever/chills were the most common side effects.
Conclusion: Both sublingual and oral 600 µg misoprostol are useful for the management of incomplete abortion. Side effects and satisfaction rates are not different. Thus, these methods may be used as alternative treatments of incomplete abortion.
© 2010 The Authors. Journal of Obstetrics and Gynaecology Research © 2010 Japan Society of Obstetrics and Gynecology.
Similar articles
-
Two routes of administration for misoprostol in the treatment of incomplete abortion: a randomized clinical trial.Contraception. 2009 Jun;79(6):456-62. doi: 10.1016/j.contraception.2008.11.016. Contraception. 2009. PMID: 19442782 Clinical Trial.
-
A randomised controlled trial of mifepristone in combination with misoprostol administered sublingually or vaginally for medical abortion up to 13 weeks of gestation.BJOG. 2005 Aug;112(8):1102-8. doi: 10.1111/j.1471-0528.2005.00638.x. BJOG. 2005. PMID: 16045525 Clinical Trial.
-
Comparative study between single dose 600 microg and repeated dose of oral misoprostol for treatment of incomplete abortion.Contraception. 2004 Oct;70(4):307-11. doi: 10.1016/j.contraception.2004.04.002. Contraception. 2004. PMID: 15451335 Clinical Trial.
-
Treatment of incomplete abortion and miscarriage with misoprostol.Int J Gynaecol Obstet. 2007 Dec;99 Suppl 2:S186-9. doi: 10.1016/j.ijgo.2007.09.009. Epub 2007 Oct 24. Int J Gynaecol Obstet. 2007. PMID: 17961569 Review.
-
The pharmacokinetics and different regimens of misoprostol in early first-trimester medical abortion.Contraception. 2006 Jul;74(1):26-30. doi: 10.1016/j.contraception.2006.03.005. Epub 2006 Apr 27. Contraception. 2006. PMID: 16781256 Review.
Cited by
-
Medical methods for first trimester abortion.Cochrane Database Syst Rev. 2022 May 24;5(5):CD002855. doi: 10.1002/14651858.CD002855.pub5. Cochrane Database Syst Rev. 2022. PMID: 35608608 Free PMC article.
-
Medical treatments for incomplete miscarriage.Cochrane Database Syst Rev. 2017 Jan 31;1(1):CD007223. doi: 10.1002/14651858.CD007223.pub4. Cochrane Database Syst Rev. 2017. PMID: 28138973 Free PMC article.
-
Medical treatment for early fetal death (less than 24 weeks).Cochrane Database Syst Rev. 2019 Jun 17;6(6):CD002253. doi: 10.1002/14651858.CD002253.pub4. Cochrane Database Syst Rev. 2019. PMID: 31206170 Free PMC article.
-
Serum biomarkers may help predict successful misoprostol management of early pregnancy failure.Reprod Biol. 2015 Jun;15(2):79-85. doi: 10.1016/j.repbio.2015.02.001. Epub 2015 Feb 11. Reprod Biol. 2015. PMID: 26051455 Free PMC article. Clinical Trial.
-
Medical treatment for early fetal death (less than 24 weeks).Cochrane Database Syst Rev. 2006 Jul 19;2006(3):CD002253. doi: 10.1002/14651858.CD002253.pub3. Cochrane Database Syst Rev. 2006. Update in: Cochrane Database Syst Rev. 2019 Jun 17;6:CD002253. doi: 10.1002/14651858.CD002253.pub4. PMID: 16855990 Free PMC article. Updated.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
