Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1990;48(3):357-69.
doi: 10.1016/0163-7258(90)90054-6.

Genetic heterogeneity of the human glutathione transferases: a complex of gene families

P Board  1 , M Coggan, P Johnston, V Ross, T Suzuki, G Webb
Affiliations
Review

Genetic heterogeneity of the human glutathione transferases: a complex of gene families

P Board et al. Pharmacol Ther. 1990.

Abstract

The glutathione transferases (GSTs) are involved in the metabolism of a wide range of compounds of both exogenous and endogenous origin. There is evidence that deficiency of GST may increase sensitivity to certain environmentally derived carcinogens. In contrast, elevated expression has been implicated in resistance to therapeutic drugs. The GSTs are the products of several gene families. This review summarizes the present knowledge of the genetic interrelationships between the various isoenzymes, their deficiencies and the physical locations of their genes.

PubMed Disclaimer

LinkOut - more resources