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Comparative Study
. 2011 Feb;33(2):145-53.
doi: 10.1002/hed.21417.

Genomic profiling of sinonasal squamous cell carcinoma

Fernando López  1 , José L Llorente, Cristina García-Inclán, Marta Alonso-Guervós, Mari Paz Cuesta-Albalad, Manuel Florentino Fresno, César Alvarez-Marcos, Carlos Suárez, Mario A Hermsen
Affiliations
Comparative Study

Genomic profiling of sinonasal squamous cell carcinoma

Fernando López et al. Head Neck. 2011 Feb.

Abstract

Background: Sinonasal squamous cell carcinomas (SCCs) are rare tumors with no etiologic link to tobacco and alcohol, as opposed to other SCCs of the head and neck (HNSCC). Little is known about the genetic changes in sinonasal SCC.

Methods: DNA copy number changes of sinonasal SCC were analyzed by multiplex ligation-dependent probe amplification (MLPA) and microarray comparative genomic hybridization (maCGH), and results were related to clinicopathologic features.

Results: Copy number losses most frequently included genes at 9p21, 13q14, 17p13, 17q21, and 18q11. Frequent gains were observed on 8q24, 11q13, 17q12, 19p13, and 20q11-q13.

Conclusion: The genomic profile of sinonasal SCC showed a number of chromosomal regions with copy number changes similar to those known in HNSCC, in spite of the differences in etiology.

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