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. 2011 Feb;33(2):251-6.
doi: 10.1002/hed.21439.

Prognostic significance of p16 in locally advanced squamous cell carcinoma of the head and neck treated with concurrent cisplatin and radiotherapy

Harold Y Lau  1 , Sony Brar, Alexander C Klimowicz, Stephanie K Petrillo, Desirée Hao, Nigel T Brockton, Christina S Kong, Susan P Lees-Miller, Anthony M Magliocco
Affiliations

Prognostic significance of p16 in locally advanced squamous cell carcinoma of the head and neck treated with concurrent cisplatin and radiotherapy

Harold Y Lau et al. Head Neck. 2011 Feb.

Abstract

Background: Human papillomavirus (HPV)-related squamous cell cancer of the head and neck (SCCHN) has emerged as a distinct clinical entity. The expression of p16 protein can be used as a surrogate for HPV status.

Methods: p16 immunohistochemistry (IHC) was assessed in archival paraffin-embedded material for 55 patients with locally advanced SCCHN treated with a uniform regimen of cisplatin and radiation. HPV status was assessed by colorimetric in situ hybridization (CISH) and polymerase chain reaction (PCR).

Results: Compared with p16- and HPV-negative patients, the p16- and HPV-positive patients had improved overall survival, disease-free survival, and locoregional recurrence rates.

Conclusions: p16 IHC may serve as a useful surrogate and prognostic marker for patients with HPV-related SCCHN treated with cisplatin and radiation.

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